Direct comparison
Cayuse vs. Streamlyne — eRA Software
Cayuse vs. Streamlyne: cloud eRA platforms for proposal, IRB/IACUC, and award management compared — codebase origin, modules, and how to evaluate them.
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How do Cayuse, Streamlyne compare side by side?
The table below compares Cayuse, Streamlyne across 10 procurement-relevant dimensions, from codebase origin through public list pricing.
Side-by-side comparison
| Dimension | Cayuse | Streamlyne |
|---|---|---|
| Codebase origin | Independently built proprietary platform | Built on the open-source Kuali Coeus codebase (Educational Community License) |
| Business model | Proprietary SaaS | Commercial hosting/support/implementation on an open-source base |
| Proposal development / pre-award | Cayuse SP (routing, budgeting) + Cayuse 424 (Grants.gov submission) | Pre-Award module, including System-to-System submission |
| IRB (human subjects) | Cayuse IRB module | IRB protocol module |
| IACUC (animal subjects) | Animal Oversight module | IACUC protocol module |
| Biosafety / IBC | Hazard Safety module | IBC coverage within compliance suite |
| Conflict of interest / export control | COI module | COI module; export control named separately in product materials |
| Post-award / award management | Award-management functionality within the Research Suite | Negotiations, Post-Award, and Subaward named as distinct module areas |
| Best-fit migration path | Institutions replacing spreadsheet/email routing or another vendor's system | Institutions migrating off an in-house Kuali Coeus deployment |
| Public list pricing | Not published; per-institution quote | Not published; per-institution quote |
Common questions
Common questions about Cayuse vs Streamlyne
Is Streamlyne the same as Kuali Research?
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No, though both descend from the same open-source Kuali Coeus codebase. Streamlyne Research and Kuali Research are separate commercial products, from separate companies, each built on that shared Coeus lineage — they are not the same product under two names.
Which is cheaper, Cayuse or Streamlyne?
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Neither vendor publishes list pricing. Cost depends on institution size, research volume, and which modules are licensed, so a direct cost comparison requires a quote from each vendor rather than a published rate.
Can an institution migrate from Kuali Coeus to either platform?
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Both are marketed as migration paths off an in-house Kuali Coeus installation, but Streamlyne's shared codebase lineage with Coeus is typically framed by the vendor as a more direct continuation, while a move to Cayuse is more of a lateral switch to an independently built platform. Migration scope and effort should be confirmed with each vendor for a specific institution's configuration.
Going deeper
